Preferred Label : Gallium Ga 68-NOTA-Aca-BBN(7-14);
NCIt synonyms : Gallium Ga 68-NOTA-Aca-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; Gallium Ga 68-NOTA-aminocaproic Acid-bombesin(7-14); 68Ga-NOTA-Aca-BBN(7-14); 68Gallium-labeled NOTA-Aca-BBN(7-14);
NCIt definition : A radioconjugate containing the bombesin (BBN) fragment BBN(7-14) comprised of the
amino acid sequence of Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, which targets the gastrin-releasing
peptide receptor (GRPR), bound to aminocaproic acid (Aca), and linked by the macrocyclic
chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), to the radionuclide
gallium (Ga) 68, with potential use in diagnostic imaging using positron emission
tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-Aca-BBN(7-14),
the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells
can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a seven-transmembrane
G protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed
in certain types of cancers.;
NCI Metathesaurus CUI : CL498292;
Origin ID : C123929;
UMLS CUI : C4086354;
Semantic type(s)
- concept_is_in_subset
