Preferred Label : Audencel;
NCIt synonyms : AV0113 Dendritic Cell Cancer Immunotherapeutic; AV0113 DC-CIT; Autologous DC-based Immunotherapeutic AV0113;
NCIt definition : A therapeutic interleukin-12 (IL-12)-expressing dendritic cell (DC)-based vaccine
composed of autologous monocyte-derived DCs loaded with autologous tumor cell lysate
and exposed to the microbial cell wall component lipopolysaccharide (LPS), with potential
immunomodulating and antineoplastic activities. The monocyte-derived immature DCs
are loaded with autologous tumor cell lysates and are subsequently exposed to LPS
and interferon-gamma (IFN-gamma). Upon administration of audencel, the mature DCs
migrate into the lymph nodes, express the immune stimulatory cytokine interleukin-12
(IL-12) and activate the immune system by promoting the activation of natural killer
(NK) cells and induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells, which may result in immune-mediated tumor cell death and inhibition of
tumor cell proliferation. Exposure to LPS and IFN-gamma allows the maturation of DCs
and optimizes the presentation of tumor-associated antigens (TAAs) by DCs to T-lymphocytes.;
UNII : H2CDQ1PWN7;
Molecule name : AV0113;
NCI Metathesaurus CUI : CL498291;
Origin ID : C123928;
UMLS CUI : C4086007;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
