NCIt definition : A long-acting, engineered and pegylated version of human granulocyte-colony stimulating
factor (G-CSF), with potential hematopoietic activity. Similar to G-CSF, pegfilgrastim
anti-neutropenic factor (ANF) binds to and activates specific cell surface receptors,
and stimulates neutrophil progenitor proliferation and differentiation. Therefore,
this agent may prevent the duration and incidence of chemotherapy-induced neutropenia.
Compared to filgrastim, the conjugation with a branched polyethylene glycol molecule
reduces renal clearance and increases its plasma half-life.;