Preferred Label : Zandelisib;
NCIt synonyms : PI3K-delta Inhibitor PWT143;
NCIt definition : An orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase
(PI3K), with potential antineoplastic activity. Upon oral administration, zandelisib
selectively inhibits the delta isoform of PI3K and prevents the activation of the
PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death
in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation
and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is
designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme
often overexpressed in cancer cells, plays a crucial role in tumor cell regulation
and survival.;
UNII : 8Z28M5SX0X;
InChIKey : WPFUFWIHMYZXSF-UHFFFAOYSA-N;
CAS number : 1401436-95-0;
Molecule name : ME 401; ME-401; PWT-143;
NCI Metathesaurus CUI : CL498289;
Origin ID : C123925;
UMLS CUI : C5418169;
Semantic type(s)
- concept_is_in_subset
- has_target
