NCIt definition : A T-cell receptor (TCR)-like monoclonal antibody against PR1, a 9 amino-acid (VLQELNVTV)
human leukocyte antigen (HLA)-A2-restricted leukemia-associated antigen (LAA) derived
from the myeloid leukemia-associated antigens proteinase 3 (P3) and neutrophil elastase
(NE), with potential immunostimulating and antineoplastic activities. Upon administration,
anti-PR1/HLA-A2 monoclonal antibody Hu8F4 selectively binds to a combined epitope
of the PR1/HLA-A2 complex expressed on acute myeloid leukemia (AML) blasts and leukemic
stem cells (LSC), and prevents PR1/HLA-A2-mediated signaling. This induces complement-dependent
cytotoxicity (CDC), to a lesser extent, antibody-dependent cell-mediated cytotoxicity
(ADCC), and CDC/ADCC-independent cytolysis of myeloid leukemia cells. This results
in a reduction of cellular proliferation in PR1/HLA-A2-overexpressing leukemic cells.
PR1 in combination with the HLA-A2 molecule is highly expressed on AML blasts and
LSCs.;
Semantic type(s)