Preferred Label : iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes;
NCIt synonyms : iAPA-DC/CTL; Inhibition of Antigen Presentation Attenuators-based Dendritic Cells/Cytotoxic T Lymphocytes;
NCIt definition : A cell-based product composed of dendritic cells (DCs) pulsed with tumor-associated
antigens (TAAs) and devoid of the inhibitory effect of antigen presentation attenuators
(iAPA) combined with cytotoxic T-lymphocytes (CTLs) (iAPA-DC/CTL), with potential
immunostimulating and antineoplastic activities. DCs are transduced with a viral vector
containing small interfering RNAs (siRNAs) against APAs, which prevents the expression
of APA genes and inhibits attenuation of antigen presentation. Upon administration
of iAPA-DC/CTL, the DCs are able to efficiently present antigens to the immune system,
stimulate the immune system against tumor-associated antigens (TAAs) and hyperactivate
TAA-specific CTLs and T-helper cells. Also, the iAPA-based DCs inhibit the activity
of the T-regulatory cells (Tregs), thereby abrogating their negative effect on CTL
activation and preventing their immunosuppressive activity against TAAs. Altogether,
this inhibits tumor cell proliferation. Additionally, the administered CTLs induce
direct cancer cell lysis. APAs negatively regulate antigen presentation, activate
Tregs and their immunosuppressive activity, affect inflammatory cytokine production
by DCs, and negatively regulate the immunostimulatory activity of DCs; they have an
overall inhibitory effect on the stimulation of the immune system.;
NCI Metathesaurus CUI : CL498286;
Origin ID : C123922;
UMLS CUI : C4086978;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
