Preferred Label : MiHA-loaded PD-L1/L2-silenced Dendritic Cell Vaccine;
NCIt synonyms : MiHA-loaded PD-L-silenced DC Vaccine;
NCIt definition : A dendritic cell (DC)-based vaccine composed of program death ligands 1 and 2 (PDL1/L2)-silenced
DCs and loaded with the recipient's minor histocompatibility antigens (MiHA), with
potential use for graft-versus-tumor (GVT) induction following allogeneic stem cell
transplantation (allo-SCT). Donor DCs are electroporated ex vivo with MiHA mRNA and
small interfering RNAs (siRNAs) designed to silence the expression of PD L1/L2. After
allo-SCT and upon intravenous administration of the MiHA-loaded PD-L1/L2-silenced
DC vaccine, the DCs induce the expansion and activation of MiHA-specific CD8-positive
T-cells. These tumor antigen-reactive T-cells exert their GVT effect by killing miHA-positive
tumor cells. PD-L1/L2, co-inhibitory ligands expressed on DCs, play key roles in preventing
MiHA-specific CD8-positive T-cell expansion; silencing enhances MiHA-specific CD8-positive
T-cell expansion and activity and improves the GVT effect. The MiHA are human leukocyte
antigen (HLA)-bound peptides and are exclusively expressed by the recipient's hematopoietic
tumor cells.;
NCI Metathesaurus CUI : CL498285;
Origin ID : C123921;
UMLS CUI : C4086570;
Semantic type(s)
- concept_is_in_subset
