Preferred Label : Ombitasvir/Paritaprevir/Ritonavir;
NCIt synonyms : OBV/PTV/r;
NCIt definition : An orally bioavailable combination agent containing ombitasvir, an inhibitor of the
hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, paritaprevir,
a synthetic acylsulfonamide inhibitor of the HCV protease complex comprised of non-structural
protein 3 and 4A (NS3/NS4A), and the cytochrome P450 (CYP) 3A4 inhibitor ritonavir,
with potential activity against HCV. Upon oral administration of ombitasvir/paritaprevir/ritonavir,
ombitasvir, enters the cell and binds to and blocks the activity of the NS5A protein.
This results in the disruption of the viral RNA replication complex, blockage of HCV
RNA production, and inhibition of viral replication. After intracellular uptake, paritaprevir
reversibly binds to the active center and binding site of the HCV NS3/NS4A protease
and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both
the processing of viral proteins and the formation of the viral replication complex,
which inhibits viral replication in HCV genotype 1-infected host cells. Although ritonavir
is not active against HCV, it strongly inhibits the activity of CYP3A4, thereby blocking
the degradation of paritaprevir, which is a CYP3A4 substrate. This leads to an increased
concentration and half-life of paritaprevir as compared to the administration of paritaprevir
without ritonavir. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein,
plays a crucial role in HCV RNA replication. NS3, a serine protease essential for
the proteolytic cleavage of multiple sites within the HCV polyprotein, plays a key
role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for
NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae
family, and infection is associated with the development of hepatocellular carcinoma
(HCC).;
Drug name : VIEKIRAX;
Origin ID : C123920;
UMLS CUI : C3864967;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
