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DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457 - CISMeF
DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457NCIt concept
Preferred Label : DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457;
NCIt synonyms : INO-3112 Vaccine; VGX-3100 Plus INO-9012;
NCIt definition : A DNA-based combination immunotherapeutic, MEDI0457, composed of VGX-3100, a preparation
of DNA plasmids encoding the E6 and E7 genes of human papillomavirus (HPV) subtypes
16 and 18, combined with INO-9012, a DNA plasmid encoding the immune activator and
pro-inflammatory cytokine human interleukin-12 (IL-12) with potential immunoactivating
and antineoplastic activities. Upon intramuscular delivery by electroporation of VGX-3100,
the HPV E6 and E7 proteins are translated in cells and elicit a cytotoxic T-lymphocyte
(CTL) response against cancer cells expressing the E6 and E7 antigens, resulting in
tumor cell lysis. HPV type 16 and HPV type 18 are associated with the development
of certain types of cancer. Upon intramuscular delivery by electroporation of INO-9012,
IL-12 is expressed and activates the immune system by promoting the activation of
natural killer cells (NK cells), inducing secretion of interferon-gamma (IFN-g) and
promoting CTL responses against tumor cells. This boosts the immune response and results
in increased CTL-mediated tumor cell death as compared with the administration of
VGX-3100 alone.;
Molecule name : MEDI 0457; MEDI-0457; INO-3112; INO 3112;
Semantic type(s)