Preferred Label : Allodepleted T Cell Immunotherapeutic ATIR101;
NCIt synonyms : Theralux-ATIR;
NCIt definition : A cell-based immunotherapeutic product containing T-lymphocyte-enriched leukocytes
that are devoid of alloreactive T-lymphocytes, that can potentially be used to restore
lymphocyte levels after stem cell transplantations and are derived from partially
matched (haploidentical) family donors for blood cancer patients who do not have a
matching stem cell donor available. Host alloreactive T-cells, which can cause graft-versus-host
disease (GVHD), are eliminated from the donor lymphocytes ex vivo using photodynamic
therapy. After allogeneic hematopoietic stem cell transplantation (HSCT), allodepleted
T cell immunotherapeutic ATIR101 is administered. This maintains a T-cell-mediated
immune response against tumor cells and the donor T-cells can prevent opportunistic
infections. ATIR101 does not cause severe, acute GVHD. In addition, administration
of ATIR101 eliminates the need for immunosuppressants.;
Drug name : Allodepleted T-cell ImmunotheRapeutics;
Molecule name : ATIR101;
NCI Metathesaurus CUI : CL498275;
Origin ID : C123911;
UMLS CUI : C4085944;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
