Preferred Label : Dasabuvir;
NCIt synonyms : N-(6-(3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; Methanesulfonamide, N-(6-(5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl)-2-naphthalenyl)-;
NCIt definition : A non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B
(NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon
administration and after intracellular uptake, dasabuvir binds HCV NS5B polymerase
and blocks viral RNA synthesis and replication. The HCV NS5B protein is essential
for the replication of the HCV RNA genome. HCV is a small, enveloped, single-stranded
RNA virus belonging to the Flaviviridae family; HCV infection is associated with the
development of hepatocellular carcinoma (HCC).;
UNII : DE54EQW8T1;
InChIKey : NBRBXGKOEOGLOI-UHFFFAOYSA-N;
CAS number : 1132935-63-7;
Drug name : Exviera;
Molecule name : ABT-333; ABT 333;
Origin ID : C123880;
UMLS CUI : C3852512;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
