Preferred Label : Ombitasvir;
NCIt synonyms : Carbamic Acid, N,N'-(((2S,5S)-1-(4-(1,1-dimethylethyl)phenyl)-2,5-pyrrolidinediyl)bis(4,1-phenyleneiminocarbonyl-(2S)-2,1-pyrrolidinediyl((1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-,
C,C'-Dimethyl Ester; L-Prolinamide,2,2'-(((2S,5S)-1-(4-(1,1-dimethylethyl)phenyl)-2,5-pyrrolidinediyl)di-4,1-phenylene)bis(N-(methoxycarbonyl)-L-valy;
NCIt definition : An orally available inhibitor of the hepatitis C virus (HCV) non-structural protein
5A (NS5A) replication complex, with potential activity against HCV. Upon oral administration
and after intracellular uptake, ombitasvir binds to and blocks the activity of the
NS5A protein. This results in the disruption of the viral RNA replication complex,
blockage of HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding
and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication.
HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae
family; HCV infection is associated with the development of hepatocellular carcinoma
(HCC).;
UNII : 2302768XJ8;
InChIKey : PIDFDZJZLOTZTM-KHVQSSSXSA-N;
CAS number : 1258226-87-7;
Molecule name : ABT-267; ABT 267;
Origin ID : C123878;
UMLS CUI : C3852670;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
