NCIt definition : An orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine
(PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159
binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational
palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation
of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in
Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays
a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of
cancers.;
UNII : 5L854240DQ;
CAS number : 1638250-96-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1638250-96-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Semantic type(s)