Preferred Label : Mulnitorsen;
NCIt synonyms : ncmtRNA Oligonucleotide Andes-1537;
NCIt definition : A proprietary antisense oligonucleotide targeting a novel non-coding mitochondrial
RNA (ncmtRNA), with potential antineoplastic activity. Upon administration, mulnitorsen
binds to ncmtRNA, which is overexpressed in rapidly proliferating cells, such as cancer
cells, and not expressed in resting cells. This may decrease the expression of the
ncmtRNA, which may inhibit cell proliferation and eventually induce apoptosis in susceptible
cancer cells. The proprietary mitochondrial RNA (mtRNA) belongs to the family of non-coding
RNAs (ncRNA); it contains an inverted repeat (IR) of 815 nucleotides (nt), which can
form a covalent link to the 5' end of the mitochondrial 16S ribosomal RNA (16S mtrRNA).;
UNII : 0DYR6BJ4AG;
CAS number : 2576358-63-7;
Molecule name : Andes-1537;
NCI Metathesaurus CUI : CL498219;
Origin ID : C123825;
UMLS CUI : C5706622;
Semantic type(s)
- concept_is_in_subset
