Preferred Label : Therapeutic Dendritic Cells/Cytokine-induced Killer Cells;
NCIt synonyms : DC-CIK;
NCIt definition : A preparation of autologous dendritic cells (DC) mixed with cytokine-induced killer
(CIK) cells (DC-CIK), with potential immunopotentiating and antineoplastic activities.
DCs were obtained ex vivo by incubation of peripheral blood lymphocytes (PBLs) with
granulocyte-macrophage colony-stimulating factor stimulating factor (GM-CSF or CSF2),
tumor necrosis factor (TNF), and interleukin (IL)-24 and were sensitized with tumor-associated
antigens (TAAs). Cytokine-induced killer (CIK) cells are immune effector cells with
both T-cell and natural killer (NK) cell like phenotype. CIKs are non-major histocompatibility
complex (MHC)-restricted, NK-like T-lymphocytes, which express both CD3, a T-cell
surface marker, and CD56, a natural killer cell surface marker, and have been generated
ex vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal
antibody, IL-2, IL-1 alpha, and interferon gamma (IFN-gamma) and then expanded. Upon
co-culture of DCs and CIKs, and administration of DC-CIK cells into the patient, the
DCs are able to stimulate the immune response to exert a specific anti-tumor immune
response, while the CIK cells exert direct oncolytic activity.;
NCI Metathesaurus CUI : CL498213;
Origin ID : C123819;
UMLS CUI : C4086900;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
