Preferred Label : 27-Hydroxycholesterol;
NCIt synonyms : Cholest-5-Ene-3beta,26-Diol, (25R)-; Cholest-5-Ene-3beta,27-Diol; Cholest-5-Ene-3,26,Diol, (3beta,25R)-; 5-Cholestene-3 beta,27-Diol; 27HC; 27OHC; (25R)-Cholest-5-Ene-3beta,26-Diol;
NCIt related terms : CHOLEST-5-ENE-3.BETA.,26-DIOL, (25R)-;
NCIt definition : An endogenous metabolite of cholesterol produced by the hydroxylation of the carbon
at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial (CYP27A1). Some
neoplasms produce excess of 27-hydroxycholesterol (27HC) or inhibit its catabolism,
and high cholesterol levels are correlated with elevated levels of 27HC; under these
conditions, 27HC may have deleterious selective estrogen receptor modulator (SERM)
and liver X receptor (LXR) agonistic activities. As a SERM, 27HC binds to and prevents
the activation of estrogen receptors (ERs) in the vasculature. This prevents ER-mediated
vasodilation and abrogates the cardiovascular protective effects of estrogen. However,
27HC binds to and activates ERs and LXRs in breast tissue, which stimulates ER-dependent
breast cancer cell growth and metastasis.;
UNII : 6T2NA6P5SQ;
CAS number : 20380-11-4;
Origin ID : C123794;
UMLS CUI : C0172934;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
