Preferred Label : Mosedipimod;
NCIt synonyms : 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol; 9,12-Octadecadienoic acid (9Z,12Z)-, 1-((Acetyloxy)methyl)-2-((1-oxohexadecyl)oxy)ethyl
Ester;
NCIt definition : A synthetic version of a monoacetyldiacylglyceride naturally occurring in various
seed oils, bovine udder and milk fat, antlers of sika deer, with potential antineoplastic
activity. Although the exact mechanism of action through which EC-18 exerts its pharmacological
effect has yet to be fully identified, upon administration, mosedipimod stimulates
calcium influx into T-lymphocytes and increases the production of various cytokines,
including interleukin (IL) -2, IL-4, IL-12, interferon-gamma (IFN-g), and granulocyte-macrophage
colony-stimulating factor (GM-CSF). This stimulates the proliferation of hematopoietic
stem cells, bone marrow stromal cells and immune cells, including T- and B-lymphocytes,
dendritic cells (DCs) and macrophages. Therefore, EC18 may stimulate the immune system
to target cancer cells. In addition, EC-18 enhances the cytolytic activity of natural
killer (NK) cells and suppresses the expression of the transmembrane protein tumor
cell toll-like receptor 4 (TLR-4) on cancer cells. As activation of TLR-4 enhances
immunosuppression and stimulates cancer cell growth, blocking TLR-4 expression suppresses
tumor cell proliferation.;
UNII : 88928BS57E;
InChIKey : GAKUNXBDVGLOFS-DUZKARGPSA-N;
CAS number : 221139-79-3;
Molecule name : EC-18;
Origin ID : C123775;
UMLS CUI : C1455477;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
