NCIt definition : Epidermal growth factor receptor protein (EGFR) bearing phosphorylated tyrosine residues
within the 194 amino acids of the carboxyl-terminal intracellular domain of the protein.
Five ligand-dependent autophosphorylation sites have been identified; overexpression
or mutation of EGFR can decouple ligand-binding from autophosphorylation and the subsequent
activation of downstream signaling pathways. The presence of phosphorylated EGFR in
a malignant tumor is generally correlated with poor prognosis and could be used as
a predictive biomarker to identify individuals who may respond to EGFR-tyrosine kinase
inhibitor treatment.;
Semantic type(s)