Preferred Label : BET Inhibitor FT-1101;
NCIt definition : An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family
of proteins, with potential antineoplastic activity. Upon administration, the BET
inhibitor FT-1101 binds to the acetylated lysine recognition motifs in the bromodomain
sites of BET proteins, thereby preventing the interaction between the BET proteins
and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention
of the expression of certain growth-promoting genes may lead to the inhibition of
tumor cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional
regulators that play an important role during development and cellular growth.;
Molecule name : FT-1101; CC-95775; CC 95775;
Origin ID : C123733;
UMLS CUI : C4053643;
Semantic type(s)
- concept_is_in_subset
- has_target
