Preferred Label : Interferon Beta-secreting Mesenchymal Stem Cells;
NCIt synonyms : MSC-IFN beta; IFNbeta-MSC; IFNb-secreting MSCs; IFNb-MSC;
NCIt definition : Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of healthy
individuals and transduced with a retroviral vector encoding the human cytokine interferon
beta (IFNb), with potential immunomodulating and antineoplastic activities. Upon administration
of IFNb-secreting MSCs, the cells are attracted and specifically migrate to tumor
sites and become part of the tumor microenvironment. Since the MSCs express IFNb,
these cells selectively deliver high levels of IFNb to the tumor site. In turn, IFNb
binds to IFN-specific cell surface receptors and modulates the transcription and translation
of certain genes whose protein products are involved in tumor cell proliferation.
This decreases tumor cell growth.;
Origin ID : C123724;
UMLS CUI : C4053520;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
