Preferred Label : EGFR Antagonist Hemay022;
NCIt synonyms : EGFR Inhibitor Hemay022;
NCIt definition : An orally available, irreversible inhibitor of epidermal growth factor receptor (EGFR),
with potential antineoplastic activity. Upon oral administration, Hemay022 covalently
binds to and inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling.
This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor
cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a
key role in tumor cell proliferation and tumor vascularization.;
Molecule name : Hemay022;
Origin ID : C123722;
UMLS CUI : C4053636;
Semantic type(s)
- concept_is_in_subset
- has_target
