Glibornuride - CISMeF

Preferred Label : Glibornuride;

NCIt synonyms : Urea, 1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)-, (1R,2R,3S,4S)-; 1-((1R)-2-endo-hydroxy-3-endo-bornyl)-3-(p-tolylsulfonyl)urea;

NCIt definition : An orally bioavailable sulfonamide urea derivative with antihyperglycemic activity. Upon administration, glibornuride binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward flow of positively charged potassium (K ) ions into the cell, and induces a calcium ion (Ca2 ) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. Insulin stimulates glycogen synthesis and inhibits gluconeogenesis, which together lower blood glucose levels.;

UNII : VP83E7434R;

InChIKey : RMTYNAPTNBJHQI-LLDVTBCESA-N;

CAS number : 26944-48-9;

Drug name : Glutril;

Molecule name : Ro 6-4563; Ro 6-4563/8;

Details

Origin ID

C123430;

UMLS CUI

C0350998;

Automatic exact mappings (from CISMeF team)
- Glibornuride [ICHI extension code]
Currated CISMeF NLP mapping
- Glibornuride [ICD-11 Extension code]
- Glibornuride (substance) [SNOMED CT concept]
- glibornuride [MeSH Supplementary Concept]
- glibornuride [MeSH concept]
- glibornuride [Substance BNPC]
See also inter- (CISMeF)
- Product containing glibornuride (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Glibornuride [ICD-11 Extension code]
- Glibornuride (substance) [SNOMED CT concept]
- Product containing glibornuride (medicinal product) [SNOMED CT concept]
- glibornuride [Substance BNPC]
- glibornuride [ATC Code]
- glibornuride [MeSH Supplementary Concept]
- glibornuride [MeSH concept]
Validated automatic mappings to BTNT
- glibornuride [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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