NCIt definition : An orally bioavailable sulfonamide urea derivative with antihyperglycemic activity.
Upon administration, glibornuride binds to and blocks the sulfonylurea receptor type
1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels
on the membranes of pancreatic beta cells. This prevents the inward flow of positively
charged potassium (K ) ions into the cell, and induces a calcium ion (Ca2 ) influx
through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing
granules. Insulin stimulates glycogen synthesis and inhibits gluconeogenesis, which
together lower blood glucose levels.;
UNII : VP83E7434R;
InChIKey : RMTYNAPTNBJHQI-LLDVTBCESA-N;
CAS number : 26944-48-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 26944-48-9
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