Preferred Label : Mimotope-P10s-PADRE Peptide Vaccine;
NCIt synonyms : P10s-PADRE Vaccine; P10s-PADRE;
NCIt definition : A peptide-based vaccine containing a carbohydrate mimetic peptide (CMP) P10s fused
to the pan HLA DR-binding epitope (PADRE) peptide, with immunomoadjuvant activity
and potential antineoplastic activity. Upon injection of the mimotope-P10s-PADRE peptide
vaccine, the P10s peptide, which mimics gangliosides and other tumor-associated carbohydrate
antigens (TACA), both stimulates a cytotoxic T-lymphocyte (CTL) response towards cells
expressing TACAs and induces the production of antibodies that are reactive with a
broad set of TACAs. Additionally, the anti-TACA antibodies may interfere with cellular
pathways involved in tumor cell survival and may induce antibody-dependent cellular
cytotoxicity (ADCC) toward cells expressing TACAs. PADRE is a helper T-cell epitope
that is able to increase the magnitude and duration of the CTL response.;
NCI Metathesaurus CUI : CL433866;
Origin ID : C123381;
UMLS CUI : C4054493;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
