Preferred Label : Ingenol Disoxate;
NCIt synonyms : 4-Isoxazolecarboxylic acid, 3,5-Diethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta(a)cyclopropa(E)cyclodecen-6-yl
Ester;
NCIt definition : A topical, aqueous gel formulation containing a derivative of ingenol, a selective
small-molecule activator of protein kinase C (PKC) that is isolated from the sap of
Euphorbia species, with the potential to treat preneoplastic skin lesions. Upon topical
application of the ingenol disoxate gel, the agent presumably activates various PKC
isoforms, which may induce apoptosis in abnormal cells found in severely sun-damaged
skin with multiple actinic keratoses. This may decrease the number of actinic keratoses
and prevent the development of skin neoplasms. The PKC family consists of signaling
isoenzymes that regulate many cell processes, including proliferation, differentiation,
and apoptosis.;
UNII : 3B100VJ4ZW;
InChIKey : GLIUZQUNUNICGS-XUBYYPQFSA-N;
CAS number : 1383547-60-1;
Molecule name : LEO 43204;
NCI Metathesaurus CUI : CL471731;
Origin ID : C123379;
UMLS CUI : C5139830;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
