" /> Eluvixtamab - CISMeF





Preferred Label : Eluvixtamab;

NCIt synonyms : BiTE Antibody AMG 330; Bispecific T-cell Engager Antibody AMG 330; CD33/CD3-directed Bispecific T-cell Engager Antibody AMG 330; Anti-CD33/CD3 BiTE Antibody AMG 330;

NCIt definition : A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) CD33 fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of eluvixtamab, this bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor cells. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on neoplastic cells in patients with acute myeloid leukemia.;

UNII : 6Z4B5PJ4OP;

CAS number : 1679391-73-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1679391-73-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AMG330; AMG 330;

Codes from synonyms : 1;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
16/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.