Preferred Label : Spiromustine;
NCIt synonyms : 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl; SHM;
NCIt related terms : Spirohydantoin mustard;
NCIt definition : A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic
properties. Containing a lipophilic hydantoin group that serves as a carrier to cross
the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers
in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking,
which may result in cytotoxicity. (NCI04);
UNII : J3HB83X76Z;
InChIKey : QNKJFXARIMSDBR-UHFFFAOYSA-N;
CAS number : 56605-16-4;
NSC code : 172112;
Codes from synonyms : NSC0172112;
Origin ID : C1233;
UMLS CUI : C0075019;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
