NCIt definition : An antibody directed against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276),
with potential immunostimulating and antineoplastic activities. Upon intravenous administration,
anti-B7-H3 antibody DS-5573a binds to the cell surface antigen B7-H3, thereby blocking
B7-H3-mediated signaling. This abrogates the inhibitory effect on T-cell activation
and may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response
against B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a
member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor
cell types and on various immune cells. It is a negative regulator of the T-cell activation
and its overexpression plays a key role in tumor cell invasion and metastasis.;