NCIt definition : An immunoglobulin (Ig) G1 humanized monoclonal antibody targeting human R-spondin
3 (RSPO3), with potential immunostimulating and antineoplastic activities. Upon intravenous
administration, rosmantuzumab targets and binds to RSPO3 expressed on tumor cells.
This prevents the activation of RSPO3, and inhibits both the binding of RSPO3 to leucine-rich
repeat-containing G-coupled receptors (LGRs) and the activation of the RSPO-LGR pathway.
This may result in an inhibition of both cancer stem cell (CSC) survival and the proliferation
of cancer cells in which this pathway is overactivated. The RSPO-LGR pathway is a
CSC pathway activated in a variety of cancer cell types.;
UNII : VD026R6TCI;
CAS number : 1684393-04-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1684393-04-1
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G-SRS /a ;
Semantic type(s)