Preferred Label : mTORC1/2 Kinase Inhibitor BI 860585;
NCIt definition : An orally bioavailable inhibitor of raptor-mammalian target of rapamycin (mTOR) complex
1 (mTOR complex 1; mTORC1) and rictor-mTOR complex 2 (mTOR complex 2; mTORC2), with
potential antineoplastic activity. Upon oral administration, mTORC1/2 kinase inhibitor
BI 860585 binds to the kinase domain of mTOR and inhibits both mTORC1 and mTORC2,
in an ATP-competitive manner. This inhibits mTOR-mediated signaling and leads to both
an induction of apoptosis and a decrease in the proliferation of mTORC1/2-expressing
tumor cells. mTOR is a serine/threonine kinase that is upregulated in certain tumor
cell types. It plays an important role in the PI3K/Akt/mTOR signaling pathway, which
is often deregulated in cancer cells and promotes cell growth, survival, and resistance
to chemotherapy and radiotherapy.;
Molecule name : BI 860585;
NCI Metathesaurus CUI : CL471745;
Origin ID : C122836;
UMLS CUI : C4053661;
Semantic type(s)
- concept_is_in_subset
