Preferred Label : Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01;
NCIt synonyms : IMPDH Inhibitor FF-10501;
NCIt definition : An orally bioavailable inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH),
with potential antineoplastic activity. Upon administration, IMPDH inhibitor FF-10501-01
competitively inhibits the enzyme IMPDH, thereby preventing the conversion of inosine
monophosphate to xanthosine monophosphate. This inhibits the synthesis of guanine
nucleotides, deprives cancer cells of guanosine triphosphate (GTP), disrupts DNA and
RNA synthesis, and decreases tumor cell proliferation. Tumor cells are highly susceptible
to IMPDH inhibition because they are rapidly dividing cells that are dependent on
rapid DNA synthesis, which requires a high concentration of nucleotides. IMPDH, an
enzyme that catalyzes the rate-limiting step in the synthesis of guanosine triphosphate
(GTP), is overexpressed in numerous tumor cell types.;
Molecule name : FF-10501-01; FF-10501;
NCI Metathesaurus CUI : CL474107;
Origin ID : C122835;
UMLS CUI : C4053644;
Semantic type(s)
- concept_is_in_subset
