Preferred Label : Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148;
NCIt synonyms : Antiviral Agent CSJ148; HCMV Neutralizing Human mAb Combination CSJ-148;
NCIt definition : A combination agent composed of two human monoclonal antibodies against the human
cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity.
Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function
of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets
and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex,
consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus
(HCMV) can cause significant disease in immunocompromised patients.;
Molecule name : LJP538 Plus LJP539; CSJ 148; CSJ-148; LJP538/LJP539;
Origin ID : C122718;
UMLS CUI : C4053652;
Semantic type(s)
- concept_is_in_subset
