Preferred Label : Suvemcitug;
NCIt synonyms : Sevacizumab;
NCIt definition : A monoclonal antibody directed against the human vascular endothelial growth factor
(VEGF), with potential antiangiogenic activity. Upon administration, suvemcitug specifically
binds to and inhibits VEGF, thereby preventing its binding to VEGF receptors (VEGFRs).
This prevents VEGF/VEGFR-mediated signaling and inhibits the proliferation of vascular
endothelial cells and tumor cells. VEGF, overexpressed in a variety of cancer cells,
is associated with increased invasiveness and decreased survival.;
UNII : T7Y5VC4ERJ;
CAS number : 1610010-57-5;
Molecule name : BD-0801; BD 0801; APX 003;
Origin ID : C122403;
UMLS CUI : C4054033;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
