Preferred Label : Autologous Oxidized Ovarian Tumor Cell Lysate Vaccine;
NCIt synonyms : Autologous OC-L Vaccine;
NCIt definition : An autologous cancer vaccine composed of oxidized ovarian tumor cell lysate, with
potential immunostimulatory and antineoplastic activities. Upon administration, the
autologous oxidized ovarian tumor cell lysate vaccine exposes the immune system to
an undefined amount of tumor-associated antigens (TAAs), which may result in the induction
of both anti-tumor cytotoxic T-lymphocytes (CTLs) and antibody-dependent responses
against TAA-expressing cells, leading to tumor cell lysis. Compared to non-oxidized
tumor cell lysate vaccines, oxidized tumor cell lysate vaccines induce necrotic cell
death, increase the immunogenicity of the TAAs and may enhance the anti-tumor immune
response.;
Origin ID : C122402;
UMLS CUI : C4055422;
Semantic type(s)
- concept_is_in_subset
