Preferred Label : Heterodimeric Interleukin-15;
NCIt synonyms : hetIL-15; IL-15/sIL-15Ra;
NCIt definition : A fusion protein complex composed of heterodimeric IL-15 (hetIL-15), which consists
of a synthetic form of the endogenous cytokine interleukin-15 chain (IL-15) complexed
to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL-15Ra) (IL15:sIL-15Ra),
with potential immunomodulatory, anti-infective and antineoplastic activities. Upon
administration, hetIL-15 binds to the IL-2/IL-15 receptor beta-common gamma chain
(IL-2Rbeta-gamma) receptor on natural killer (NK) and T-lymphocytes, which activates
and increases the levels of NK cells and CD8 and CD4 T-cells. The T-cells enhance
the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates
the immune response against tumor cells. Altogether, this enhances tumor cell killing
and decreases tumor cell proliferation. By coupling IL-15 to IL15Ra, this agent has
an improved pharmacokinetic profile, shows an increased ability to bind IL-2Rbeta-gamma,
and shows increased immunostimulatory activity as compared to IL-15 alone.;
Origin ID : C122401;
UMLS CUI : C4053488;
Semantic type(s)
- concept_is_in_subset
