Preferred Label : Synthetic Hypericin;
NCIt synonyms : Topical SGX301;
NCIt definition : A topical ointment formulation containing a synthetic form of hypericin, an anthraquinone
derivative that is naturally found in the yellow flower of Hypericum perforatum (St.
John's wort), with potential antineoplastic and photosensitizing activities. Upon
topical administration of the ointment to the tumor site, hypericin becomes activated
through the application of visible fluorescent light. During photoactivation, hypericin
generates singlet oxygen, which induces DNA damage, necrosis and apoptosis, thereby
inhibiting tumor cell growth. The use of visible light for activation avoids the risk
of developing secondary malignancies, which are frequently associated with other photodynamic
therapies that are dependent on ultraviolet A exposure.;
Origin ID : C122400;
UMLS CUI : C4053962;
Semantic type(s)
- concept_is_in_subset
