Preferred Label : Hypomethylation Therapy;
NCIt synonyms : Hypomethylating Agent-Based Therapy; Hypomethylating Therapy;
NCIt definition : Therapies that target the activity of DNA methyltransferases. Hypomethylating agents,
including azacitidine and decitabine, have been used in the therapy of myelodysplastic
syndrome and secondary acute myeloid leukemia. Although it is not curative, it can
induce an improvement in hematopoiesis and lead to prolonged overall survival. Use
of hypomethylating agents in the treatment of sickle cell anemia and other hemoglobin
disorders can trigger the expression of fetal hemoglobin, leading to significant improvements
in clinical symptoms.;
Origin ID : C122369;
UMLS CUI : C4054751;
Semantic type(s)
- concept_is_in_subset
