Preferred Label : BROCA Gene Signature;
NCIt synonyms : BROCA - Cancer Risk Panel;
NCIt definition : A prognostic system used to assess if a patient has an increased risk for developing
hereditary cancer, with a focus on ovarian and breast cancers. This system is based
on the use of massively parallel DNA sequencing to detect cancer predisposing mutations
in a panel of more than 45 specific genes.;
NCIt note : There have been several versions of the BROCA panel. As of June 2015, the BROCA test
examines mutations in the following genes: AKT1, APC, ATM, ATR, AXIN2, BAP1, BARD1,
BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK1, CHEK2, CTNNA1, FAM175A (Abraxas),
FH, FLCN, GALNT12, GEN1, GREM1, HOXB13, MEN1, MLH1, MRE11A, MSH2 ( EPCAM), MSH6, MUTYH,
NBN, NF1, PALB2, PALLD, PIK3CA, PMS2, POLD1, POLE, POT1, PRKAR1A, PRSS1, PTCH1, PTEN,
RAD51B, RAD51C, RAD51D, RB1, RET, RINT1, RPS20, SDHB, SDHC, SDHD, SLX4, SMAD4, SMARCA4,
STK11, TP53, VHL, and XRCC2. (http://tests.labmed.washington.edu/BROCA);
Origin ID : C121989;
UMLS CUI : C4055392;
Semantic type(s)
- concept_is_in_subset
