Preferred Label : B Acute Lymphoblastic Leukemia, BCR-ABL1-Like;
NCIt synonyms : Ph-Like ALL; B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features; B Lymphoblastic Leukemia, Philadelphia-like; B-Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features; B Acute Lymphoblastic Leukemia with BCR::ABL1-Like Features; B-Acute Lymphoblastic Leukemia with BCR::ABL1-Like Features; B-Lymphoblastic Leukemia, Philadelphia-like; Ph-Like Acute Lymphoblastic Leukemia; B-Acute Lymphoblastic Leukemia, BCR-ABL1-Like; B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like; B Acute Lymphoblastic Leukemia, BCR::ABL1-Like;
NCIt related terms : Ph-Like; BCR-ABL1-like Acute Lymphoblastic Leukemia; BCR-ABL1-like ALL; Philadelphia-Like Acute Lymphoblastic Leukemia; Philadelphia-like ALL; BCR::ABL1-like features;
NCIt definition : B acute lymphoblastic leukemia characterized by a gene-expression profile similar
to that of BCR-ABL1-positive B acute lymphoblastic leukemia, absence of the pathognomonic
BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a
poor outcome.;
Alternative definition : NICHD: A subtype of high risk B cell acute lymphoblastic leukemia (ALL) in which patients
have a gene-expression profile similar to that of BCR-ABL1 positive ALL, but who all
lack the BCR-ABL1 fusion gene. Similar to patients with BCR-ABL1 positive ALL, patients
with Ph-like ALL frequently harbor alterations in lymphoid transcription factors.
This is clinically important because of the presence of kinase-activating alterations
that are amenable to treatment with currently available tyrosine kinase inhibitors.
This subtype occurs in 10-15% of pediatric ALL patients and increases in frequency
with age.;
Neoplastic status : Malignant;
Origin ID : C121974;
UMLS CUI : C4054188;
Disease excludes abnormal cell
- Disease excludes normal cell origin
- Disease may have findings
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_excludes_molecular_abnormality
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_molecular_abnormality
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_may_have_associated_disease
- disease_may_have_molecular_abnormality
