Preferred Label : Docetaxel Nanoparticle CPC634;
NCIt synonyms : Docetaxel containing CriPec (R) Nanoparticles; Nanoparticle-encapsulated Docetaxel CPC634; Docetaxel-containing CriPec (R) Nanoparticles CPC634;
NCIt definition : A polymeric nanoparticle (PNP) formulation containing the poorly water-soluble taxane
docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity.
Upon intravenous administration of the docetaxel nanoparticle CPC634, the nanoparticles
are able to accumulate at the tumor site due to the unique characteristics of the
tumor's vasculature, while avoiding normal, healthy tissue. In turn, docetaxel is
released locally at the target tumor site, binds specifically to the beta-tubulin
subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly,
which results in cell-cycle arrest at the G2/M phase, thereby preventing cell proliferation.
This agent also inhibits pro-angiogenic factors such as vascular endothelial growth
factor (VEGF) and induces various mediators of the inflammatory response. Compared
to docetaxel alone, this formulation may enhance stability and improve delivery, thereby
increasing docetaxel's efficacy while avoiding systemic exposure, which minimizes
its toxicity.;
Drug name : CriPec (R) Docetaxel;
Molecule name : CPC 634; CPC-634;
Origin ID : C121961;
UMLS CUI : C5203803;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
