Preferred Label : Pirotinib;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinase (RTK) epidermal growth
factor receptor (ErbB; EGFR) family, with potential antineoplastic activity. Upon
administration, pirotinib selectively and irreversibly binds to and inhibits the epidermal
growth factor receptors 1 (ErbB1; EGFR), 2 (ErbB2; HER2), and 4 (ErbB4; HER4). This
may result in the inhibition of cell growth and angiogenesis in tumors overexpressing
these RTKs. EGFRs play major roles in both tumor cell proliferation and tumor vascularization,
and are overexpressed in many cancer cell types.;
Molecule name : KBP-5209;
Origin ID : C121960;
UMLS CUI : C4054177;
Semantic type(s)
- concept_is_in_subset
- has_target
