Preferred Label : Gallium Ga 68-NOTA-AE105;
NCIt synonyms : 68Ga-NOTA-AE105;
NCIt definition : A radiotracer composed of AE105, an urokinase-type plasminogen activator receptor
(uPAR) peptide antagonist, conjugated with the bifunctional, macrocyclic chelating
agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the
radionuclide gallium Ga 68, with potential imaging activity using positron emission
tomography (PET). Upon administration, the AE105 moiety of gallium Ga 68-NOTA-AE105
targets and binds, with high affinity, to uPAR expressed on tumor cells. Upon PET
imaging, uPAR-expressing tumor cells can be visualized and the degree of tumor aggressiveness
can be assessed. uPAR expression is correlated with increased tumor invasiveness and
aggressiveness, as well as a poor prognosis.;
Origin ID : C121954;
UMLS CUI : C4054906;
Semantic type(s)
- concept_is_in_subset
