Preferred Label : pan-RAF Kinase Inhibitor CCT3833;
NCIt definition : An orally available inhibitor of the serine/threonine protein kinase family Raf, including
A-Raf, B-Raf and C-Raf, with potential antineoplastic activity. Upon administration,
pan-RAF kinase inhibitor CCT3833 inhibits Raf-mediated signal transduction pathways,
which may inhibit the proliferation of Raf-overexpressing tumor cells. Raf protein
kinases play a key role in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular
signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human
cancers and plays a key role in tumor cell proliferation and survival.;
Molecule name : CCT3833; BAL3833;
Origin ID : C121952;
UMLS CUI : C4053656;
Semantic type(s)
- concept_is_in_subset
