Preferred Label : Xanthohumol;
NCIt synonyms : 3'-[3,3-Dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone;
NCIt definition : A prenylated flavonoid derived from the female flowers of the hops plant (Humulus
lupulus L), with potential chemopreventive and antineoplastic activities. Upon administration,
xanthohumol scavenges reactive oxygen species (ROS), thereby preventing DNA damage
due to oxidative stress. In addition, xanthohumol is able to increase the expression
of phase II cytoprotective enzymes, thereby inactivating carcinogens. This agent exerts
anti-inflammatory activity, through the inhibition of inflammation-inducing enzymes,
inhibits DNA synthesis, and induces apoptosis of susceptible cancer cells. Xanthohumol
also decreases the expression of C-X-C chemokine receptor 4 (CXCR4), thereby preventing
cancer cell invasion.;
UNII : T4467YT1NT;
CAS number : 6754-58-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 6754-58-1
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G-SRS /a ;
Origin ID : C121950;
UMLS CUI : C0536128;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
