Preferred Label : Copper Cu 64-DOTA B-Fab;
NCIt synonyms : 64 Cu-DOTA B-Fab; 64 Cu-DOTA DS6 B-Fab; Cu 64-labeled B-Fab DS6 Antibody-like Binding Protein;
NCIt definition : A radioimmunoconjugate containing a bivalent monospecific tandem immunoglobulin fragment
(B-Fab) derived from the humanized monoclonal antibody DS6 targeting the tumor-associated
mucin-1 (MUC1)-sialoglycotope CA6 conjugated with the bifunctional, macrocyclic chelating
agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) and labeled
with the radioisotope copper Cu 64 with potential use as an imaging agent for CA6-expressing
tumors using positron emission tomography (PET). The B-Fab moiety of Copper Cu 64-DOTA
B-Fab binds, with high affinity, to the cell surface antigen CA6. Upon binding, the
radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification
of CA6-expressing tumor cells. This tracer could be used to select patients who could
benefit from and to monitor efficacy of CA6-targeted anti-cancer therapies. Compared
to DS6, the antibody fragment allows for increased tumor penetration, faster blood
clearance, and more rapid renal elimination. The CA6 epitope is found on a variety
of solid tumors.;
Origin ID : C121928;
UMLS CUI : C4055180;
Semantic type(s)
- concept_is_in_subset
- has_target
