Giant Cell Lesion of Small Bones

Preferred Label : Giant Cell Lesion of Small Bones;

NCIt synonyms : Giant Cell Reparative Granuloma; GCLSB;

NCIt definition : A rare tumor-like lesion of the hands and feet characterized by the presence of hemorrhagic fibrous tissue, hemosiderin deposition, osteoclast-like giant cells which are irregularly distributed, and reactive bone formation. Pain and swelling are the most frequent symptoms. It may recur following curettage, but is usually cured after a second procedure.;

Neoplastic status : Benign;

Details

Origin ID

C121893;

UMLS CUI

C4049867;

Disease excludes abnormal cell
- Malignant Cell [NCIt concept]
- Malignant Mesenchymal Spindle Cell [NCIt concept]
- Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell [NCIt concept]
Excludes anatomical site(s)
- Lymphatic System [NCIt concept]
Has associated anatomic sites
- Bone [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Musculoskeletal System [NCIt concept]
See also inter- (CISMeF)
- Giant cell reparative granuloma [ACR pathology]
- giant cell reparative granuloma [DO Concept]
- granuloma, giant cell [MeSH Descriptor]
- granuloma, giant cell reparative [MeSH concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Locally Aggressive Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Giant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Osteoclast-Like Giant Cell [NCIt concept]
disease_has_finding
- Benign Cellular Infiltrate [NCIt concept]
- Fibrosis [NCIt concept]
- Hemorrhagic Change [NCIt concept]
- Hemosiderin Deposition [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Lytic Bone Lesion [NCIt concept]
- New Bone Formation [NCIt concept]
- Pain [NCIt concept]
- Swelling [NCIt concept]
disease_has_normal_cell_origin
- Cell [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone [NCIt concept]
- Musculoskeletal System [NCIt concept]
disease_mapped_to_gene
- USP6 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- USP6 Gene Rearrangement [NCIt concept]
pathogenesis_of_disease_involves_gene
- USP6 Gene [NCIt concept]
- USP6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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