Preferred Label : Cetuximab Sarotalocan Sodium;
NCIt synonyms : Cet-IR700; Cetuximab-IR700 Conjugate RM-1929;
NCIt definition : The sodium salt form of cetuximab sarotalocan, which consists of a chemical conjugate
composed of the dye IR700 linked to cetuximab, a monoclonal antibody directed against
the epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
Upon injection of cetuximab sarotalocan sodium, the cetuximab moiety targets and binds
to EGFR-expressing tumor cells, resulting in the internalization of the conjugate.
Upon localized application of near-infrared (NIR) light, the IR700 dye becomes activated,
disrupts the cell membrane and selectively kills the EGFR-expressing tumor cells.
EGFR, a tyrosine kinase receptor, is overexpressed in a variety of cancers.;
UNII : MG94W1I5XW;
CAS number : 2166339-33-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2166339-33-7
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G-SRS /a ;
Molecule name : RM-1929; ASP-1929; ASP 1929;
Origin ID : C121850;
UMLS CUI : C5706621;
Semantic type(s)
- concept_is_in_subset
- has_target
