Preferred Label : Ezobresib;
NCIt synonyms : BET Inhibitor BMS-986158;
NCIt definition : An inhibitor of the Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins,
with potential antineoplastic activity. Upon administration, ezobresib binds to the
acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction
between BET proteins and acetylated histones. This disrupts chromatin remodeling and
prevents the expression of certain growth-promoting genes, resulting in an inhibition
of tumor cell growth. BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional
regulators that bind to acetylated lysines on the tails of histones H3 and H4, and
regulate chromatin structure and function; they play an important role in the modulation
of gene expression during development and cellular growth.;
UNII : X8BW0MQ5PI;
CAS number : 1800340-40-2;
Molecule name : BMS-986158;
Origin ID : C121849;
UMLS CUI : C5908079;
Semantic type(s)
- concept_is_in_subset
- has_target
