Preferred Label : Fucosylated Umbilical Cord Blood Regulatory T Cells;
NCIt synonyms : Fucosylated UCB Tregs;
NCIt definition : Fucosylated, human umbilical cord blood (UCB)-derived regulatory T-cells (Tregs),
with potential immunomodulating activity. Ex vivo, Tregs are isolated from cord blood,
expanded, and fucosylated. Upon infusion, the fucosylated UCB Tregs modulate immune
responses and induce tolerance to allogeneic transplants, such as hematopoietic stem
cell transplants (HSCTs). This suppresses graft-versus-host disease (GVHD). Fucosylation
improves the activity of Tregs and reduces the amount of Tregs that need to be expanded
and infused.;
Origin ID : C121830;
UMLS CUI : C4054923;
Semantic type(s)
- concept_is_in_subset
