Mivebresib - CISMeF

Preferred Label : Mivebresib;

NCIt synonyms : Ethanesulfonamide, N-(4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo(2,3-C)pyridin-4-yl)phenyl)-;

NCIt definition : An inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, mivebresib binds to the acetyl-lysine binding site of BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors.;

UNII : VR86R11J7J;

InChIKey : RDONXGFGWSSFMY-UHFFFAOYSA-N;

CAS number : 1445993-26-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1445993-26-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABBV-075;

Details

Origin ID

C121829;

UMLS CUI

C4724809;

Currated CISMeF NLP mapping
- mivebresib [MeSH Supplementary Concept]
- mivebresib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mivebresib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Bromodomain Testis-Specific Protein [NCIt concept]
- Bromodomain-Containing Protein 2 [NCIt concept]
- Bromodomain-Containing Protein 3 [NCIt concept]
- Bromodomain-Containing Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients