Rhizoxin - CISMeF

Preferred Label : Rhizoxin;

NCIt definition : A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit endothelial cell-induced angiogenic activity, which may result in decreased tumor cell proliferation. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It comes from a fungus and is similar to vinca alkaloid drugs. It belongs to the family of drugs called antimitotic agents.;

UNII : C1V1Y784E4;

CAS number : 90996-54-6;

Molecule name : WF-1360;

NSC code : 332598;

Codes from synonyms : CDR0000045392;

Details

Origin ID

C1218;

UMLS CUI

C0073184;

Currated CISMeF NLP mapping
- rhizoxin [MeSH concept]
- rhizoxin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- rhizoxin [MeSH concept]
- rhizoxin [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Microtubule [NCIt concept]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Microtubule Polymerization [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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